Efeitos da glutamina na saúde intestinal: uma revisão sistemática

Abstract

The aim of this systematic review is to demonstrate the results of published studies on glutamine outcomes and bowel health effects. Scientific articles published without time frame in the scientific databases PubMed, SciELO and Virtual Health Library were investigated. The search was performed using the following descriptors glutamine AND intestinal function, glutamine AND intestine with the use of the Boolean AND operator. The POT strategy (population, outcome and type of study), ), defined the guiding question. The work followed PRISMA standards for its structure, the criteria for the research were defined and 9 works were selected to compose the review. The results of the studies show the effects of glutamine supplementation in significantly improving intestinal permeability in critically ill patients in major surgery, cancer, sepsis, among other situations that lead to amino acid depletion. Glutamine works to improve gastrointestinal symptoms caused by acute diarrhea, irritable bowel syndrome and chron's disease, and may constitute an essential factor in the well-being and good intestinal health of individuals. The results of this systematic review present evidence of the effects of glutamine on the intestinal barrier. New studies must be carried out to standardize the doses, as there is no consensus on the dosage of glutamine, possible side effects, time of supplementation to be offered so that its indication reaches safe levels.